Azithromycin eye ointment is used to treat ear, nose, throat, chest, skin and soft tissue infections (acne, tooth infection), and s**ually transmitted disease (like syphilis). To apply eye ointment , wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.If you are using this medication for the first time, hold the ointment upright and remove the cap. This will release any extra pressure in the dropper. Put the cap back on before shaking the dropper.